The Super is primarily a bridge position pickup, although it can be used in the neck position with a relatively low-gain amp. Specifically designed for solid-bodies; hollow and semi-hollow guitars can be hard to control with warm, high output pickups.

When DiMarzio first built the Super, it was a one-conductor pickup. As a 4-conductor pickup, it's extremely versatile. Coil splitting produces a very Strat-like option, both in tone and power. Parallel wiring is similar to splitting, but it's still humbucking and a little more hollow sounding; Paul Gilbert used to use 2 Supers wired in parallel when he was in Racer X.